The value of electron microscopy in the diagnosis of renal disease
DOI:
https://doi.org/10.20883/jms.2016.9Keywords:
renal biopsy, kidney, electron microscopyAbstract
In the literature of recent years there are few publications on the importance of research in electron-microscopic pathomorphological diagnosis of kidney disease. The most important, which is diagnosed only on the basis of these studies are: minimal change disease, assessment of mesangial cell proliferation as well as the differentiation of the types of membranoproliferative glomerulonephritis, fibrillary glomerulonephritis, lupus nephritis, thin basement membrane disease, Alport syndrome, hemolytic-uremic syndrome. This report presents the most characteristic features of the ultrastructure allowing for diagnosis of these diseases.Downloads
References
Alwall N. Aspiration biopsy of the kidney, including i.a. a report of a case of amyloidosis diagnosed through aspiration biopsy of the kidney in. 1944 and investigated at an autopsy in 1950. Acta Med Scand. 1952;143:430–435.
Iversen P, Brun C. Aspiration biopsy of the kidney. Am J Med. 1951;11:324–330.
Fogo AB, Cohen AH, Colvin RB, Jennette JCh, Alpers ChE. Minimal change disease and focal segmental glomerulosclerosis. In: Fundamentals of Renal Pathology. 2nd ed. Springer-Verlag Berlin Heidelberg. 2014: 45–58.
Bonsib S. Podocytopathies. Minimal change disease. In: Atlas of Medical Renal Pathology. Springer Science+Business Media New York. 2013: 201–202.
Bhasin H, Abuelo J, Nayak R, Esparza A. Mesangial proliferative glomerulonephritis. Lab Invest. 1978;39:21–29.
Kashgarian M. Mesangium and glomerular disease. Lab Invest. 1985;52:569–571.
D`Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med. 1987;64:709–727.
Emancipator SN. Current concept in renal pathology. IgA nephropathy: morphologic expression and pathogenesis. Am J Kidney Disease. 1994;23:451–462.
Salwa-Żurawska W, Bortkiewicz E, Woźniak A, Szumińska- Napiontek E, Warzywoda A, Maciejewski J, Kaczmarek J, Dworacki G. Mesangial glomerulonephritis (GNMes) in children. Diagnostic problems, usefulness of repeated biopsy. Pol J Pathol. 1994;45:291–298.
Habib R, Gubler MC, Loirat C, Mäiz HB, Levy M. Dense deposit disease; a variant of membranoproliferative glomerulonephritis. Kidney Int. 1975;7:204–215.
Cameron JS, Turner DR, Heaton J, Williams DG, Ogg CS, Chantler C, Haycock GB, Hicks J. Idiopatic mesangio-capillary glomerulonephritis. Comparison of types I and II in children and adults in long- term prognosis. Am J Med. 1983;74:175–192.
Muda AO, Barsotti P, Marinozzi V. Ultrastructural histochemical investigations of “dense deposit disease”. Pathogenetic approach to a special type of mesangiocapillary glomerulonephritis. Virchows Archiv A Pathol Anat. 1988;413:529–537.
Fogo AB, Cohen AH, Colvin RB, Jennette JCh, Alpers ChE. Membranoproliferative glomeulonephritis and C3 glomerulopathy. In: Fundamentals of Renal Pathology. 2nd ed. Springer-Verlag Berlin Heidelberg. 2014: 31–43.
Salwa-Żurawska W, Bortkiewicz E, Woźniak A, Dworacki G, Maciejewski J. Morphological and clinical aspects of membrano-proliferative glomerulonephritis in children Pol J Pathol. 1996;47:215–224.
Duffy JL, Khurana E, Susin M, Gomez- Leon G, Churg J. Fibrillary renal deposits and nephritis. Am J Pathol. 1983;113:279–290.
Nasr SH, Valeri AM, Cornell LD, Fiedler ME, Sethi S, Leung N, Fervenza FC. Fibrillary glomerulonephritis: a raport of 66 cases from a single institution. Clin J Am Soc Nephrol. 2011;6:775–784.
Fogo AB, Cohen AH, Colvin RB, Jennette JCh, Alpers ChE. Fibrillary glomerulonephritis. In: Fundamentals of Renal Pathology. 2nd ed. Springer-Verlag Berlin Heidelberg. 2014: 191–192.
Garancis JC, Komorowski RA, Bernhard GC, Straumfjord JV. Significance of cytoplasmic microtubules in lupus nephritis. Am J Pathol. 1971;64:1–12.
Norton W. Endothelial inclusions in active lesion of systemic lupus erythematosus. J Lab and Clin Med. 1969;74:369–371.
Tisher CC, Kelso HB. Intraendothelial inclusions in kidneys of patients with systemic lupus erythematosus Ann Int Med. 1971;75:537–541.
Salwa W, Topiłko A. Ultrastructural glomerular lesions in cases with minimal involvement by systemic lupus erythematosus. Folia Histochem Cytochem. 1973;11:351–352.
Topiłko A, Salwa W. Struktury wtrętowe (wirusopodobne) w śródbłonku kłębuszków nerkowych. Pat Pol. 1973;24:403–408.
Kashgarian M. The role of the kidney biopsy in the treatment of lupus nephritis. Ren Fail. 1996;18:765–773.
Dische FE, Weston MJ, Parsons V. Abnormally thin glomerular basement membranes associated with hematuria, proteinuria or renal failure in adults. Am J Nephrol. 1985;5:103–109.
Mandache E, Gherghiceanu M. Ultrastructural defects of glomerular basement membrane associated with primary glomerular nephropathies. Ultrastruct Pathol. 2004;28:103–108.
Forster K, Markowitz GS, D`Agati VD. Pathology of this basement membrane nephropathy. Semin Nephrol. 2005;25:149–158.
Tryggvason K, Patrakka J. Thin basement membrane nephropathy J Am Soc Nephrol. 2006;17:813–822.
Żurawski J, Salwa-Żurawska W, Woźniak A, Bortkiewicz E, Maciejewski J, Idasiak-Piechocka I, Urbański B. Clinical and morphological aspects of thin glomerular basement membrane disease. Pol J Pathol. 2009;1:35–42.
Colvin RB. Thin basement membrane disease in diagnostic pathology. Kidney Disease. Amirsys. 2011: 296–297.
Liapis H, Godken N, Hmiel P, Miner JH. Histopathology, ultrastructure and clinical phenotypes in thin glomerular membrane disease variants. Hum Pathol. 2002;33:836–845.
Spear GS, Slusser RJ. Alport`s syndrome. Emphasizing electron microscopic studies of the glomerulus. Am J Pathol. 1972;69:213–224.
Rumpelt HJ. Alport`s syndrome: specifity and pathogenesis of glomerular basement alterations. Pediatr Nephrol. 1987;1:422–427.
Meleg- Smith S. Alport disease: a review of the diagnostic difficulties. Ultrastruct Pathol. 2001;25:193–200.
Thorner PS. Alport syndrome and thin basement nephropathy. Nephron Clin Pract. 2007;106:82–88.
Koitabashi Y, Rosenberg BF, Shapiro H, Bernstein J. Mesangiolysis: an important glomerular lesion in thrombotic microangiopathy. Mod Pathol. 1991;4:161–166.
Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol. 2005;16:1035–1050.
Fogo AB, Cohen AH, Colvin RB, Jennette JCh, Alpers ChE. Thrombotic microangiopathies. In: Fundamentals of Renal Pathology. 2nd ed. Springer-Verlag Berlin Heidelberg. 2014: 138–142.
Shigematsu H, Dikman SH, Churg J, Grishman E, Duffy JL. Mesangial involvement in hemolytic-uremic syndrome. A light and electron microscopic study. Am J Pathol. 1976;85:349–362.
Ben-Bassad M, BraslavskyD, Loton D, Eisnstein B, Dawidowitz M, Stark H. Ultrastructural changes suggestive of focal segmental glomerulosclerosis in atypical minimal change nephrotic syndrome. Ultrastruct Pathol. 1988;12:1–16.
Chiang M, Hawkins EP, Berry PL, Barrish J, Hill LL. Diagnostic and prognostic significance of gromelular epithelial cell vacuolization and podocyte effacement in children with minimal lesion nephrotic syndrome and focal segmental glomerulosclerosis: an ultrastructural study. Clin Nephrol. 1988;30:8–14.
Salwa-Żurawska W, Bortkiewicz E, Turczuk-Bierła I, Maciejewski J. Focal, segmental glomerulosclerosis in children. Pathol Pol. 1992;43:45–50.
Salwa-Żurawska W, Woźniak A, Biczysko W, Bortkiewicz E, Kaczmarek E, Maciejewski J. Is vacualisation of podocytes and glomerular endothelial cells prognostic value with respekt to FSGS? Pol J Pathol. 1998;49:165–174.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Jakub Żurawski, Aldona Woźniak, Wiesława Salwa-Żurawska
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
