Real-time quality control for chemical and biotechnological processes: a brief review

Agnieszka Kołodziejczak-Radzimska; Beata Rukowicz; Sharon Davin

doi:10.20883/medical.e901

Authors

Agnieszka Kołodziejczak-Radzimska Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Poland https://orcid.org/0000-0002-5338-0436
Beata Rukowicz Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, Poland https://orcid.org/0000-0002-1304-3638
Sharon Davin APC – Applied Process Company Ltd., Dublin, Ireland https://orcid.org/0000-0003-0578-8741

DOI:

https://doi.org/10.20883/medical.e901

Keywords:

Process Analytical Technology (PAT), Real-Time Process Control, Online Analysis, Monitoring Techniques

Abstract

Monitoring critical process parameters of chemical and biotechnological processes is an essential tool at every stage of drug manufacturing technology. The aim of Process Analytical Technology (PAT) is to provide effective tools, such as multidimensional data analysis, modern analytical methods, and monitoring tools, for the continuous improvement of process understanding and knowledge. Among the methods of wide interest are optical and spectroscopic techniques that can be used in the control of chemical and biotechnological processes. The selection of the appropriate method is crucial and depends on many factors, including the nature of the process, the number of variables, and analytical limitations. This review focuses on a brief and precise characterization of spectroscopic and optical methods that can be applied to monitoring and control of chemical and biotechnological processes.

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