Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol

Klaudia Łochocka; Aleksandra Glapa; Jan Krzysztof Nowak; Monika Duś-Żuchowska; Katarzyna Grabańska; Paweł Bogdański; Ewa Fidler; Edyta Mądry; Jarosław Walkowiak

doi:10.20883/medical.e86

Authors

Klaudia Łochocka Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Aleksandra Glapa Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Jan Krzysztof Nowak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Monika Duś-Żuchowska Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Katarzyna Grabańska Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poland
Paweł Bogdański Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Poland
Ewa Fidler Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland
Edyta Mądry Department of Physiology, Poznan University of Medical Sciences, Poland
Jarosław Walkowiak Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland

DOI:

https://doi.org/10.20883/medical.e86

Keywords:

obesity, randomized, digestion, absorption, body composition, lipid profile, endothelial dysfunction, mineral status, breath test, 13C, adipokines

Abstract

This is the protocol of a study aiming to assess the impact of conjugated linoleic acid (CLA) on anthropometric parameters, body composition and densitometric parameters, carbohydrate and fat digestion and absorption, total energy expenditure, glucose and insulin homeostasis, lipid profile, adipokines concentrations, polyunsaturated fatty acids levels, markers of endothelial dysfunction and mineral status in humans. Seventy-four adult volunteers (BMI ≥ 25 kg/m2) will be randomized to receive 3.0 g of 80% CLA (50:50 cis-9, trans-11 and trans-10, cis-12 isomers) or 3.0 g of linoleic acid daily for 3 months. A range of parameters will be measured at baseline and after the intervention.

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