Cerebrovascular mediated subclinical brain injury – interaction between cardiovascular function, brain structure and cognitive function – study rationale, design and principal methods

Katarzyna Katulska; Andrzej Minczykowski; Jarosław Piskorski; Mateusz Wykrętowicz; Marek Stajgis; Przemysław Guzik; Andrzej Wykrętowicz

doi:10.20883/medical.e65

Authors

Katarzyna Katulska Department of Radiology, Poznan University of Medical Sciences, Poland
Andrzej Minczykowski Department of Cardiology – Intensive Therapy, Poznan University of Medical Sciences, Poland
Jarosław Piskorski Institute of Physics, University of Zielona Góra, Poland
Mateusz Wykrętowicz Department of Radiology, Poznan University of Medical Sciences, Poland
Marek Stajgis Department of Radiology, Poznan University of Medical Sciences, Poland
Przemysław Guzik Department of Cardiology – Intensive Therapy, Poznan University of Medical Sciences, Poland
Andrzej Wykrętowicz Department of Cardiology – Intensive Therapy, Poznan University of Medical Sciences, Poland

DOI:

https://doi.org/10.20883/medical.e65

Keywords:

brain structure, cognitive function, arterial stiffness, arterio-vascular coupling, gray matter volume, white matter lesions

Abstract

Project entitled “Cerebrovascular mediated subclinical brain injury – interaction between cardiovascular function, brain structure and cognitive function- study rationale, design and principal methods” is a cross-sectional study in a group of older individuals with no apparent symptoms of stroke, transient ischemic attacks or cognitive impairment. The primary aim of the projects is further our understanding of the patomechanism of cerebrovascular disease associate brain injury as well as vascular cognitive impairment and give a better insight into the interplay between arterial wall, ventriculo-vascular coupling, wave reflection and pulsatility of the flow and how these interplays are mirrored by MRI neuroimaging. With our novel, interdisciplinary approach, we will define the methodology and build tools for those who want to follow in this challenging and non-standard direction.

Downloads

Download data is not yet available.

References

Longstreth WT Jr, Bernick C, Manolio TA, Bryan N, Jungreis CA, Price TR. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol. 1998;55:1217–25.

Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O’Leary D, Fried L. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people:the Cardiovascular Health Study. Stroke. 1996;27:1274–82.

Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, Vinters HV, Holtzman DM, Rosenberg GA, Wallin A, Dichgans M, Marler JR, Leblanc GG. National Institute of Neurological Disorders and Stroke – Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006;37:2220–41.

Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O’Brien JT, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391–8.

Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O’Donnell CJ, Yoshita M, D’Agostino RB Sr, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke. 2008;39:2929–35.

Debette S, Beiser A, DeCarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS, Wolf PA, Seshadri S. Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study. Stroke. 2010; 41:600–6.

Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O’Donnell CJ, Yoshita M, D’Agostino RB Sr, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke. 2008;39:2929–35.

O’RourkeMF, Hashimoto J, Mechanical factors in arterial aging. J Am Coll Cardiol. 2007;50:1–13.

Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, Simonsick EM, Havlik R, Lakatta EG, Spurgeon H, Kritchevsky S, Pahor M, Bauer D, Newman A for the Health ABC Study et al. Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation. 2005;111:3384–90.

Boutouyrie P, Tropeano AI, Asmar R, Gautier I, Benetos A, Lacolley P, Laurent S. Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study. Hypertension. 2002;39:10–15.

Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects > 70 years of age. Arterioscler Thromb Vasc Biol. 2001;21:2046–50.

Henskens LH, Kroon AA, van Oostenbrugge RJ, Gronenschild EH, Fuss-Lejeune MM, Hofman PA, Lodder J, de Leeuw PW. Increased aortic pulse wave velocity is associated with silent cerebral small-vessel disease in hypertensive patients. Hypertension. 2008;52:1120–6.

Kearney-Schwartz A, Rossignol P, Bracard S, Felblinger J, Fay R, Boivin JM, Lecompte T, Lacolley P, Benetos A, Zannad F. Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints. Stroke. 2009;40:1229–36.

Bhattacharya P, Bao F, Shah M, Ramesh G, Madhavan R, Khan O. Left ventricular dysfunction is associated with grey matter injury: an in vivo brain MRI segmentation study. J Neurosci Sci. 2012;321:111–3.

Katulska K, Wykrętowicz M, Minczykowski A, Krauze T, Milewska A, Piskorski J, Marciniak R, Stajgis M, Wysocki H, Guzik P, Wykrętowicz A. Aortic excess pressure and arterial stiffness in subjects with subclinical white matter lesions. Int J Cardiol. 2014;1;172:269–70.

Katulska K, Wykrętowicz M, Minczykowski A, Krauze T, Milewska A, Piskorski J, Marciniak R, Stajgis M, Wysocki H, Guzik P, Wykrętowicz A. Grey matter volume in relation to left ventricular end-systolic stiffness, arterial stiffness and central pressure augmentation. J Neurol Sci (submitted).

Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test manual – adult version (research edition). The Psychological Corporation, New York 1987.

Hunt SM, McKenna SP, McEwen J, Williams J, Papp E. The Nottingham Health Profile: subjective health status and medical consultations. Soc Sci Med A. 1981;15:221–9.

Ruff RM, Light RH, Parker SB, Levin HS. Benton Controlled Oral Word Association Test: reliability and updated norms. Arch Clin Neuropsychol. 1996;11:329–38.

Reitan RM. Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills. 1958; 8:271–6.

Wechsler D. Wechsler Adult Intelligence Scale. Manual. The Psychological Corporation, New York 1955.

Wrześniewski K. Development of a Polish version of the Nottingham Health Profile. Quality of Life Research. 2000;25:20–2.