Sympathetic Nervous System activity – a new concept of the complicated etiology of low back pain radiates distally at the extremities

Authors

  • Elżbieta Skorupska Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poland
  • Magdalena Atarowska Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poland
  • Włodzimierz Samborski Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poland

DOI:

https://doi.org/10.20883/medical.e44

Keywords:

sciatica, neuropathic pain, low back pain, quantitative sensory testing

Abstract

Varied and complicated etiology of low back pain radiates distally at the extremities is still causing disagreement and controversies around the issue of its diagnosis and treatment. New research data demonstrated that almost one in five persons with back pain experience symptoms indicative of neuropathic pain component. The neuropathic involvement is not completely understood, and different mechanisms are thought to play important role. A combination of nociceptive and neuropathic pain-generating mechanism is thought to be involved, which established the term mixed pain syndrome. In the pathomechanism of neuropathic pain the lesion, trauma or overloading of the disc is thought to be a primary source of the neuropathic pain but the concept of neuropathic component of pain is more probable for chronic stage than acute. Assessment of neuropathic pain involves a systematic approach which includes a series steps; past and present history, detailed description of pain distribution, quality, pain intensity and neurological examination with emphasis on sensory testing. The sensory examinations need often to be supply neurophysiological testing and quantitate sensory testing. Some groups of the drugs are thought to be useful e.g. tricyclic antidepressant, sodium channel blockers (e.g. carbamazepine), gabapentin, opioids, NMDA (N-methyl-D-aspartate) receptor blockers and others for neuropathic pain treatment. The use of specific kind of the drugs depends on the symptoms and examinations findings.

Downloads

Download data is not yet available.

References

Freynhagen R, Rolke R, Baron R et al. Pseudoradicular and radicular low-back pain – A disease continuum rather than different entities? Answers from quantitative sensory testing. Pain. 2008;135:65–74.

Aota Y, Niwa T, Yoshikawa K, Fujiwara A, Asada T, Saito T. Magnetic Resonance Imaging and Magnetic Resonance Myelography in Presurgical Diagnosis of Lumbar Foraminal Stenosis. Spine. 2007;32(8):896–903.

Bennett MI, Smith BH, Torrance N, Lee AJ. Can pain be more or less neuropathic? Comparison of symptom assessment tools with ratings of certainty by clinicians. Pain. 2006;122:289–94.

Freynhagen R, Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep. 2009;13(3):185–90.

Waddell G, McCulloch JA, Kummel ED, Venner RM. Nonorganic physical signs in low back pain. Spine. 1980;5(2):117–25.

Wolf A, Wilder-Smith O. Diagnosis in patients with chronic radiating low back pain without overt focal neurological deficits: What is the value of segmental nerve root blocks? Therapy. 2005;2:577–85.

Buijs E, Visser L, Groen G. Sciatica and sacroiliac joint: a forgotten concept. Br J Anaesthesia. 2007;99(5):713–6.

Kelly M. Is pain due to pressure on nerves? Spinal tumors and the intervertebral disc. Neurology. 1956;6(1):32–6.

Lindahl O, Rexed B. Histological changes in spinal nerve roots of operated cases of sciatica. Acta Orthop Scand. 1951;20(3):215–25.

McCarron RF, Wimpee MW, Hudkins PG, Laros GS. The inflammatory effects of nucleus pulposus. A possible element in the pathogenesis of low back pain. Spine. 1987;12(8):760–4.

Takahashi K, Shima I, Porter RW. Nerve root pressure in lumbar disc herniation. Spine. 1999;24(19):2003–6.

Ahmed M, Modic MT. Neck and low back pain: neuroimaging. Neurol Clin. 2007;25:439–471.

Boden SD, Davis DO, Dina TS. Abnormal magnetic resonance scans of the lumbar spine in asymptomatic subjects: a prospective investigation. J Bone Joint Surg. 1990;72(3):403–8.

Boss N, Semmer N, Elfering E et al. history of individuals with asymptomatic disc abnormalities in magnetic resonance imaging. Spine. 2000;25(12):1484–92.

Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331(2):69–73.

Porchet F, Wietlisbach V, Burnard B, Daeppen K, Villemure JG, Vader JP. Relationship between severity of lumbar disc disease and disability stores in sciatica patients. Neurosurgery. 2002;50(6):1253–9.

Garfin SR, Rydevik BL, Brown RA. Compressive neuropathy of spinal nerve roots. A mechanical or biological problem? Spine. 1991;16(5):162–6.

Rydevik BL, Pedowitz RA, Hargens AR, Swenson MR, Myers RR, Garfin SR. Effects of acute, graded compression on spinal nerve root function and structure. An experimental study of the pig cauda equine. Spine. 1991;16:487–93.

Rubinstein SM, van Tulder M. A best-evidence review of diagnostic procedures for neck and low-back pain. Best Pract Res Clin Rheumatol. 2008;22(3):471–82.

Rolke R. Pseudoradicular and radicular low-back pain – A disease continuum Rather than different entities? Reply to the letters by Leffler and Hansson and by Van Boxem et al. Pain. 2008;135:311–316.

Hall T, Zusman M, Elvey R. Manually detected impediments during the straight leg raise test. MPAA Conference Proceedings 9th Biennial Conference, 1995:48–53.

Backup K. Clinical test for the musculoskeletal system. Examination-Signs-Phenomena. 2ed edition Thieme; 2008.

Goeken LN, Hof AL. Instrumental straight-leg raising: a new approach to Lasegue’s test. Arch Phys Med Rehabil. 1991;72(12):959–66.

Bennett MI, Attal N, Backonja MM et al. Using screening tools to identify neuropathic pain. Pain. 2007:127:199–203.

Jensen TS, Gottrup H, Sindrup SH, Bach FW. The clinical picture of neuropathic pain. Eur J Pharm. 2001;429:1–11.

Moskowitz MH. Pharmacotherapy of neuropathic low back pain. Curr Pain Headache Rep. 2003;7(3):178–87.

Downloads

Published

2014-03-30

Issue

Section

Review Papers

How to Cite

1.
Skorupska E, Atarowska M, Samborski W. Sympathetic Nervous System activity – a new concept of the complicated etiology of low back pain radiates distally at the extremities. JMS [Internet]. 2014 Mar. 30 [cited 2024 Dec. 22];83(1):53-6. Available from: https://jmsnew.ump.edu.pl/index.php/JMS/article/view/44