Study of serum metabolic profiles of patients with non-small cell lung cancer with special emphasis on the smoking status of patients

Agnieszka Klupczynska; Mariusz Kasprzyk; Wojciech Dyszkiewicz; Marcin Grabicki; Halina Batura-Gabryel; Zenon J. Kokot; Jan Matysiak

doi:10.20883/jms.317

Authors

Agnieszka Klupczynska Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0002-5028-1408
Mariusz Kasprzyk Department of Thoracic Surgery, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0001-6553-7675
Wojciech Dyszkiewicz Department of Thoracic Surgery, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0001-6259-7381
Marcin Grabicki Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0002-6469-9469
Halina Batura-Gabryel Department of Pulmonology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0003-4555-7905
Zenon J. Kokot Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0003-4950-9759
Jan Matysiak Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Poland https://orcid.org/0000-0002-9993-1504

DOI:

https://doi.org/10.20883/jms.317

Keywords:

lung cancer, metabolomics, chronic-obstructive pulmonary disease, mass spectrometry

Abstract

The project entitled “Study of serum metabolic profiles of patients with non-small cell lung cancer with special emphasis on the smoking status of patients” is a study based on metabolomics, which is the latest of the “omics” technologies and involves a comprehensive analysis of small molecule metabolites of a specific biological sample. High-throughput and sensitive analytical techniques used in metabolomic investigations are powerful tools in the field of oncology and aids understanding what is happening in cancer cells and searching for new cancer markers. The aim of the project is to determine whether lung cancer patients have a distinct serum metabolic profile and whether this profile is associated with patients’ smoking status. The application of liquid chromatography-high-resolution mass spectrometry-based methodology along with advanced statistical methods will enable to select potential molecules that can be useful in early lung cancer detection.

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