Characteristics of Regulatory T cells

Magdalena Frydrychowicz; Maciej Boruczkowski; Agata Kolecka-Bednarczyk; Renata Jenek; Joanna Rosołowska; Agnieszka Pluto-Prądzyńska; Grzegorz Dworacki

doi:10.20883/jms.2016.175

Authors

Magdalena Frydrychowicz Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Maciej Boruczkowski Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Agata Kolecka-Bednarczyk Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Renata Jenek Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Joanna Rosołowska Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Agnieszka Pluto-Prądzyńska Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland
Grzegorz Dworacki Chair and Department of Clinical Immunology, Poznan University of Medical Sciences, Poland

DOI:

https://doi.org/10.20883/jms.2016.175

Keywords:

Tregs, regulatory T cells, autoimmunity, cancer

Abstract

Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4⁺CD25^-). CD25, CD45Ro, CD152, GITR, LAG-3, several adhesion molecules, chemokine receptors as well as Toll-like receptors are present on the surface of Treg. Mechanism of suppression used by nTreg is not completely understood.

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