Selected issues of GABA metabolism and its potential role in neuropsychiatric disorders.

Andrzej Kostyrko

doi:10.20883/jms.2017.145

Authors

Andrzej Kostyrko Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences

DOI:

https://doi.org/10.20883/jms.2017.145

Keywords:

ABAT, GABA, interneurons, autism, bipolar disorder, schizophrenia

Abstract

This mini review is limited to chosen problems about GABA metabolism mainly in aspect of associated disorders. GABA primarily identified as inhibitory neurotransmitter plays also excitatory function. Abundant investigations concern the role of GABA in forming and development of neuronal structures in the brain. Resolving of this basic questions will allow to understand the etiology of related neuropsychiatric disorders.

Downloads

Download data is not yet available.

References

Brady RO, McCarthy JM, Prescot AP, Jensen JE, Cooper AJ, Cohen BM et al. Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder. Bipolar Disord. 2013 Jun;15(4):434–439.

Fishell G, Rudy B. Mechanisms of inhibition within the telencephalon: ”where the wild things are”. Annu Rev Neurosci. 2011;34:535–567.

Klausberger T, Somogyi P. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science. 2008 Jul;321(5885):53–57.

Le Magueresse C, Monyer H. GABAergic interneurons shape the functional maturation of the cortex. Neuron. 2013 Feb;77(3):388–405.

Super H, Martínez A, Del Río JA, Soriano E. Involvement of distinct pioneer neurons in the formation of layer-specific connections in the hippocampus. J Neurosci. 1998 Jun;18(12):4616–4626.

Soriano E, Cobas A, Fairén A. Asynchronism in the neurogenesis of GABAergic and non-GABAergic neurons in the mouse hippocampus. Brain Res. 1986 Nov;395(1):88–92.

Pleasure SJ, Anderson S, Hevner R, Bagri A, Marin O, Lowenstein DH et al. Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons. Neuron. 2000 Dec;28(3):727–740.

Brambilla P, Perez J, Barale F, Schettini G, Soares JC. GABAergic dysfunction in mood disorders. Mol Psychiatry. 2003 Aug;8(8):721–737.

Fatemi SH, Halt AR, Stary JM, Kanodia R, Schulz SC, Realmuto GR. Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices. Biol Psychiatry. 2002 Oct 15;52(8):805–10.

Ohlson J, Pedersen JS, Haussler D, Ohman M. Editing modifies the GABA(A) receptor subunit alpha3. RNA. 2007 May;13(5):698–703.

Rula EY, Lagrange AH, Jacobs MM, Hu N, Macdonald RL, Emeson RB. Developmental modulation of GABA(A) receptor function by RNA editing. J Neurosci. 2008 Jun;28(24):6196–6201.

Yuan H, Low CM, Moody OA, Jenkins A, Traynelis SF. Ionotropic GABA and glutamate receptor mutations and human neurologic diseases. Mol Pharmacol. 2015 Jul;88(1):203–217.

Gambardella A, Manna I, Labate A, Chifari R, La Russa A, Serra P et al. GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy. Neurology. 2003 Feb 25;60(4):560–563.

Parviz M, Vogel K, Gibson KM, Pearl PL. Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies. J Pediatr Epilepsy. 2014 Nov;3(4):217–227.

Wang PW, Sailasuta N, Chandler RA, Ketter TA. Magnetic resonance spectroscopic measurement of cerebral gamma-aminobutyric acid concentrations in patients with bipolar disorders. Acta Neuropsychiatr. 2006 Apr;18(2):120–126.

Besse A, Wu P, Bruni F, Donti T, Graham BH, Craigen WJ et al. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. Cell Metab. 2015 Mar;21(3):417–427.

Stein V, Nicoll RA. GABA generates excitement. Neuron. 2003 Feb;37(3):375–378.

Gulledge AT, Stuart GJ. Excitatory actions of GABA in the cortex. Neuron. 2003 Jan;37(2):299–309.

Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics. 2007 Jan-Mar;2(1):29–36.

Tao R, Li C, Newburn EN, Ye T, Lipska BK, Herman MM et al. Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders. J Neurosci. 2012 Apr;32(15):5216–5222.

Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J et al. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov;468(7321):263–269.