Neurological and renal complications in obese children with cancer: a systematic review of cardiovascular risk factors

Roghayeh Mohseni; Mostafa Hamid; Mohammad Saleh Sadri; Sannar Sattar  Albuzyad; Pedram Ramezani

doi:10.20883/medical.e1245

Authors

Roghayeh Mohseni Shiraz University of Medical Sciences, Shiraz, Iran https://orcid.org/0000-0003-1715-7082
Mostafa Hamid Department of Nursing, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran https://orcid.org/0009-0002-4333-3158
Mohammad Saleh Sadri Department of Anesthesiology, Modares Hospital, Saveh University of Medical Sciences, Saveh, Iran https://orcid.org/0000-0002-8967-9050
Sannar Sattar Albuzyad Imam Khomeini Hospital, Tehran, Iran https://orcid.org/0009-0009-0086-1939
Pedram Ramezani General Iractitioner, Tehran Azad University, Tehran, Iran https://orcid.org/0009-0009-2919-1959

DOI:

https://doi.org/10.20883/medical.e1245

Keywords:

obesity, pediatric cancer, neurological complications, renal complications, cardiovascular risk factors

Abstract

Obesity in children, especially those with cancer, is a growing concern due to its impact on health outcomes. These children are at increased risk for neurological, renal, and cardiovascular complications, which can worsen their prognosis. This systematic review aims to examine the role of obesity in the development of these complications in children with cancer, highlighting the associated cardiovascular risk factors. A comprehensive literature search was conducted across databases such as PubMed, Scopus, Web of Science, Embase, and Google Scholar for studies published between 2014 and 2025. Eligible studies included interventional, cohort, case-control, and observational studies that examined the impact of cancer treatments on neurological and renal outcomes in obese pediatric patients. The review followed PRISMA guidelines to ensure methodological rigor, with quality assessment using validated tools such as the Newcastle-Ottawa Scale and STROBE checklist. Thirteen studies involving 14,723 participants met the inclusion criteria. Obesity was associated with poorer survival outcomes, particularly in children with ALL and CNS tumors, showing lower EFS and OS rates. Obese children undergoing chemotherapy had higher incidences of treatment-related toxicities, including hepatotoxicity, nephrotoxicity, and thrombotic events. Renal complications, including acute kidney injury and electrolyte imbalances, were more prevalent in obese patients. Obesity also increased cardiovascular risk, with higher rates of hypertension and insulin resistance. Additionally, it contributed to neurocognitive impairments and poor psychosocial outcomes. Lastly, obesity affected growth trajectories, with many survivors remaining obese long-term. Early weight management and personalized treatment strategies are crucial to mitigate these risks. Addressing obesity in pediatric cancer care is essential to improve treatment outcomes and long-term survivorship, with further research needed to develop effective interventions.

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Author Biographies

Roghayeh Mohseni, Shiraz University of Medical Sciences, Shiraz, Iran

Master of Medical Education, Non-communicable Diseases Expert
Mohammad Saleh Sadri, Department of Anesthesiology, Modares Hospital, Saveh University of Medical Sciences, Saveh, Iran

Anesthesiologist
Sannar Sattar Albuzyad, Imam Khomeini Hospital, Tehran, Iran

MBBS, Radiologist

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